publication2

Selected Publications

(View full publications on Google Scholar ) (# co-first author, ∗ corresponding author)

Zhengjie Zhou#, Jiayu Zhu#, Ru-Ting Huang, Angelo Meliton, David Wu, Tony Pan, Nick Asby, Erica Budina, Aaron Alpar, Jeffrey Hubbell, Jun Huang, Gökhan M. Mutlu, Matthew V. Tirrell∗, and Yun Fang∗
Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis. bioRxiv. Nat. Biomed. Eng., In Revision. 2025.
Highlighted in Science News: https://www.science.org/content/article/new-nanoparticle-therapies-target-two-major-killers, doi:10.1126/science.zqbtd4b.

     Access the paper:  
  • PMID:
  • Biorxiv Preprint: 632179
  • Full Text

  • Jacob R. Enriquez#, Zhengjie Zhou# (co-first author), Jennifer B. Nelson, Fei Huang, Brian Xi, Yun Fang∗, and Raghavendra G. Mirmira∗
    Messenger RNA Delivery to Islet beta-cells Using Functionalized Lipid Nanoparticles. Cell Rep. Med., In Revision. 2025

         Access the paper:  
  • PMID:
  • Full Text

  • Zhengjie Zhou, Lauryn Carver, Tzu-Han Lee, Nickolai Dulin, Matthew V. Tirrell∗, and Yun Fang∗
    Targeted TXNDC5 inhibition in activated lung fibroblasts by fluorinated nanoparticles treating lung fibrosis. In submission. 2025

         Access the paper:  
  • PMID:
  • Full Text

  • Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myugn-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V. Tirrell∗, and Yun Fang∗
    Targeted polyelectrolyte complex micelles treat vascular complications in vivo. PNAS. 2021

         Access the paper:  
  • PMID: 34880134
  • Full Text

  • Zhengjie Zhou, Yang Yan, Qiang Zhang∗, and Yiyun Cheng∗
    Melanin-like nanoparticles loaded with angiotensin antagonist for improved photothermal cancer therapy. Biomater. Sci., 2020

         Access the paper:  
  • PMID: 31971526
  • Full Text

  • Zhengjie Zhou#, Yang Yan#, Li Wang, Qiang Zhang∗, and Yiyun Cheng∗
    Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy. Biomaterials. 2019

         Access the paper:  
  • PMID: 30852424
  • Full Text

  • Zhengjie Zhou#, Tianqi Fan#, Yang Yan#, Song Zhang, Yi Zhou, Hanbin Deng, Xiaopan Cai, Jianru Xiao, Dianwen Song, Qiang Zhang∗ and Yiyun Cheng∗
    One stone with two birds: Phytic acid-capped platinum nanoparticles for targeted combination therapy of bone tumors. Biomaterials. 2019

         Access the paper:  
  • PMID: 30593938
  • Full Text

  • Zhengjie Zhou, Yang Yan, Kewen Hu, Yuan Zou, Yiwen Li, Rui Ma, Qiang Zhang∗, and Yiyun Cheng∗
    Autophagy inhibition enabled efficient photothermal therapy at a mild temperature. Biomaterials. 2017

         Access the paper:  
  • PMID: 28675807
  • Full Text

  • Zhengjie Zhou#, Yitong Wang#, Yang Yan, Qiang Zhang∗, and Yiyun Cheng∗
    Dendrimer-templated ultrasmall and multifunctional photothermal agents for efficient tumor ablation. ACS Nano. 2016

         Access the paper:  
  • PMID: 27054555
  • Full Text

  • Zhengjie Zhou, Kewen Hu, Rui Ma, Yang Yan, Bing Ni, Yunjiao Zhang, Longping Wen, Qiang Zhang∗, and Yiyun Cheng∗
    Dendritic platinum–copper alloy nanoparticles as theranostic agents for multimodal imaging and combined chemophotothermal therapy. Adv. Funct. Mater. 2016

         Access the paper:  
  • PMID:
  • Full Text
  • Patents

    1. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating lung disorders, 2023, MBHB Ref. No. 22-0856-WO

    2. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating arterial disease, 2023, MBHB Ref. No. 22-0857-WO

    3. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating fabrotic lung disorders, 2023, MBHB Ref. No. 21-0632-WO

    4. Fang Y, Mirmira R, Zhou Z, Enriquez J. Targeted nanomedicine for treating diabetes. 2025, MBHB Ref. No. 24-0108-WO