Zhengjie Zhou#, Jiayu Zhu#, Ru-Ting Huang, Angelo Meliton, David Wu, Tony Pan, Nick Asby, Erica Budina, Aaron Alpar, Jeffrey Hubbell, Jun Huang, Gökhan M. Mutlu, Matthew V. Tirrell∗, and Yun Fang∗
Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis. bioRxiv. Nat. Biomed. Eng., In Revision. 2025.
Highlighted in Science News: https://www.science.org/content/article/new-nanoparticle-therapies-target-two-major-killers, doi:10.1126/science.zqbtd4b.
Jacob R. Enriquez#, Zhengjie Zhou# (co-first author), Jennifer B. Nelson, Fei Huang, Brian Xi, Yun Fang∗, and Raghavendra G. Mirmira∗
Messenger RNA Delivery to Islet beta-cells Using Functionalized Lipid Nanoparticles. Cell Rep. Med., In Revision. 2025
Zhengjie Zhou, Lauryn Carver, Tzu-Han Lee, Nickolai Dulin, Matthew V. Tirrell∗, and Yun Fang∗
Targeted TXNDC5 inhibition in activated lung fibroblasts by fluorinated nanoparticles treating lung fibrosis. In submission. 2025
Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myugn-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V. Tirrell∗, and Yun Fang∗
Targeted polyelectrolyte complex micelles treat vascular complications in vivo. PNAS. 2021
Zhengjie Zhou, Yang Yan, Qiang Zhang∗, and Yiyun Cheng∗
Melanin-like nanoparticles loaded with angiotensin antagonist for improved photothermal cancer therapy. Biomater. Sci., 2020
Zhengjie Zhou#, Yang Yan#, Li Wang, Qiang Zhang∗, and Yiyun Cheng∗
Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy. Biomaterials. 2019
Zhengjie Zhou#, Tianqi Fan#, Yang Yan#, Song Zhang, Yi Zhou, Hanbin Deng, Xiaopan Cai, Jianru Xiao, Dianwen Song, Qiang Zhang∗ and Yiyun Cheng∗
One stone with two birds: Phytic acid-capped platinum nanoparticles for targeted combination therapy of bone tumors. Biomaterials. 2019
Zhengjie Zhou, Yang Yan, Kewen Hu, Yuan Zou, Yiwen Li, Rui Ma, Qiang Zhang∗, and Yiyun Cheng∗
Autophagy inhibition enabled efficient photothermal therapy at a mild temperature. Biomaterials. 2017
Zhengjie Zhou#, Yitong Wang#, Yang Yan, Qiang Zhang∗, and Yiyun Cheng∗
Dendrimer-templated ultrasmall and multifunctional photothermal agents for efficient tumor ablation. ACS Nano. 2016
Zhengjie Zhou, Kewen Hu, Rui Ma, Yang Yan, Bing Ni, Yunjiao Zhang, Longping Wen, Qiang Zhang∗, and Yiyun Cheng∗
Dendritic platinum–copper alloy nanoparticles as theranostic agents for multimodal imaging and combined chemophotothermal therapy. Adv. Funct. Mater. 2016
1. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating lung disorders, 2023, MBHB Ref. No. 22-0856-WO
2. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating arterial disease, 2023, MBHB Ref. No. 22-0857-WO
3. Fang Y, Zhou Z, Tirrell M, Targeted nanomedicine for treating fabrotic lung disorders, 2023, MBHB Ref. No. 21-0632-WO
4. Fang Y, Mirmira R, Zhou Z, Enriquez J. Targeted nanomedicine for treating diabetes. 2025, MBHB Ref. No. 24-0108-WO